You may found in this page all the options available in in General Preferences configuration section.

...

When this option is enabled, Test Runs can be executed inline, directly from the Test Execution issue view page. This option is only available if the final Test Run Status (above) can be manually set.

Fail All Steps/Examples

When this option is enabled, whenever the status of a Test Run is changed to FAIL, than all the Test Steps/Examples Statuses will also be updated to FAIL.

Restrict automated Test status

When this option is enabled, the status of automated Test Runs can't be set manually. It can only be modified through the import of automated test results action.

Can Edit TestRun Dates

When this option is enabled, the user can edit the Started On and Finished On dates in the Test Execution Details page. 

Defect Issue Links

Options related to Defect issue creating in the test execution context.

...

Resolved Test Execution workflow status

Choose what workflow status the test execution will transition to when all the test runs are in a final status.

Resolution for Resolved Test Execution

Choose what resolution will be applied to the test execution. This option is only available when if the Resolved Test Execution workflow status is different from none. The resolution is only changed for status of type done.

Defect Default Values

Environment

...

When this option is enabled, the Affect Version field of the defects created in the context of a test run will be populated by FixVersion value of Test Execution.

Label

The defects created in the context of a test run are populated with the "Label" value from the Issue Type selected in this field

Miscellaneous

Display Pre-Condition section before Test Details

...